• Major Instruments & Facilities
• Research scholars
• Latest Research Team

Department of Pharmacology and Toxicology has the facilities to carry out pharmacological screening of NCEs. The department can enter into project collaborations in regulatory toxicological testing, viz., acute, sub-chronic and chronic toxicity testing. The departmental research activities are concentrated in the following areas:

• Opioid tolerance, supersensitivity and dependence mechanisms
• Role of different subtypes of angiotensin receptors in hypertension and diabetic vascular complications
• Understanding the mechanisms of diabetic complication and development of NIDDM & insulin resistance models in rodents; screening of synthetic and natural products for their antidiabetic activity
• Role of alpha adrenoceptors in benign prostatic hyperplasia
• Understanding the molecular mechanisms involved in ischaemic stroke
• Evaluation of novel neuroprotective approaches for the treatment of cerebral ischemia
• Development of animal models of cerebral ischemia
• Understanding the mechanisms of diabetic neuropathy
• Role of adenosine receptors subtypes in diabetic neuropathic pain
• Evaluation of various neuroprotective approaches in diabetic neuropathy
• Screening of NCEs for antileismanial activity.
• Development of rat model for Alzheimer's disease and screening of NCEs on learning and memory in rats
• Production of monoclonal antibodies against Plasmodium yoelii nigeriensis antigens with the objective of characterization of protective antigens
• Molecular mechanisms of protection, cytoadherence, immune evasion and red cell invasion in malaria
• Biotherapeutics and chemotherapeutics evaluation of potential antimalarial, antitubercular, antileishmanial and antiamoebic agents in vitro and in vivo
• Study of the opioids-induced bidirectional molecular signaling within the neuroimmune network with a view to develop new immunomodulators.
• Histone modifications as targets for drug discovery
• Molecular mechanism involved in toxicant and oxidative stress induced process of cell death

Technologies Available

• "Ets-1 identifying RNA aptamer for Cancer Therapeutics" by the inventors Prof. K.B Tikoo and Jasmine Kaur. [Indian Patent Application No. 1623/DEL/2014]