Regulatory Toxicology
To understand the toxicity of chemicals (NCEs, Pharmaceuticals and pollutants) and the principles of regulatory compliance. To evaluate different toxicity end-points using regulatory test guidelines and GLP principles. To establish and validate new test model development, test integration as well as to resolve issues & awareness in different gray areas of toxicology.
 

DNA damage, autophagy and carcinogenesis
Quantification of DNA damage using different bio assays (CA, MN, COMET) and molecular targets (Nrf2, P53, NF-kB)
 

Correlation between different levels (tissue, cell, DNA, somatic vs germinal, transplacental vs neonatal) of organizations and end- points of evaluations for determination of assay sensitivity and specificity.
To Explore new areas (germinal, intestinal and neuronal) for DNA damage detection and the influence on autophagy for different target organs of clinical significance.
 

Chemical intervention in Pathological Models
Exacerbation and amelioration of chemical toxicity (DNA damage, cell proliferation, fibrosis and germ cell damage) under Diabetic (Type I and II) condition. To understand the influence of trace elements, vitamins & inflammation in DNA damage, and cellular senescence.