Synthetic Organic Medicinal Chemistry

• Anticancer drug discovery: Design and synthesis of heterocyclic compounds as human DNA topoisomerase IIα inhibitors, Microtubule-dynamics inhibitors, DNA polymerases inhibitors, and their SAR studies
• Antileishmanial drug discovery: Design and synthesis of heterocyclic compounds as target-specific antileishmanial agents
• Network-linked polypharmacology-based drug discovery
• Natural product-inspired, Scaffold-hopping, and Choice-based change medicinal chemistry strategies
• Creating new from clinical trial agents and drugs; Exploration of patentable bioactive chemotypes
• Identification of target-specific unique pharmacophore motifs
• Structural modulations linked to pharmacodynamics, drug-likeness and pharmacokinetic-relevant physicochemical properties
• Synthesis of natural product-based compounds (structural elaborated, simplified and analog)
• Synthetic methodology development: Construction of pharmaceutically-privileged heterocyclic molecular skeletons, SAR/molecular diversity-enabled approach
• Chemistry: C-H bond functionalization, Ylide chemistry, Synthon, Isocyanide-based reactions, Catalysis, Green chemistry