Host-Pathogen interaction during Infection
The emergence of drug resistant strains of tuberculosis has contributed to the fact that Mycobacterium tuberculosis remains one of the most successful pathogens. Research has been initiated in the area of host –pathogen interaction using cell biology and recombinant DNA based approaches. The main focus is on identifying multifunctional housekeeping enzymes of the host and pathogen that could be essential in the process of infection and survival of intracellular M.tuberculosis. In addition, a screening assay for anti-mycobacterials is also being developed. Other areas of interest are Iron metabolism and Immune signalling